MicroRNAs in Sarcopenia: A Systematic Review

Katsunori Yanai; Shohei Kaneko; Hiroki Ishii; Akinori Aomatsu; Kiyonori Ito; Keiji Hirai; Susumu Ookawara; Kenichi Ishibashi; Yoshiyuki Morishita

doi:10.3389/fmed.2020.00180

MicroRNAs in Sarcopenia: A Systematic Review

Front Med (Lausanne). 2020 May 28:7:180. doi: 10.3389/fmed.2020.00180. eCollection 2020.

Authors

Katsunori Yanai¹, Shohei Kaneko¹, Hiroki Ishii¹, Akinori Aomatsu^{1

2}, Kiyonori Ito¹, Keiji Hirai¹, Susumu Ookawara¹, Kenichi Ishibashi³, Yoshiyuki Morishita¹

Affiliations

¹ Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
² Division of Intensive Care Unit, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
³ Department of Medical Physiology, Meiji Pharmaceutical University, Tokyo, Japan.

Abstract

Sarcopenia, which is characterized by the loss of skeletal muscle, has been reported to contribute to development of physical disabilities, various illnesses, and increasing mortality. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit translation of target messenger RNAs. Previous studies have shown that miRNAs play pivotal roles in the development of sarcopenia. Therefore, this systematic review focuses on miRNAs that regulate sarcopenia.

Keywords: microRNA; myoblast; myocyte; myotube; sarcopenia; systematic review.

Publication types

Systematic Review