Patient-Derived HIV-1 Nef Alleles Reveal Uncoupling of CD4 Downregulation and SERINC5 Antagonism Functions of the Viral Pathogenesis Factor

J Acquir Immune Defic Syndr. 2020 Oct 1;85(2):e23-e26. doi: 10.1097/QAI.0000000000002418.

Authors

Benedikt Obermaier^{1

2}, Swetha Ananth^{1

2}, Nadine Tibroni¹, Virginia Pierini¹, Iart L Shytaj^{1

2}, Ricardo S Diaz³, Marina Lusic^{1

2}, Oliver T Fackler^{1

2}

Affiliations

¹ Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany.
² German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.
³ Infectious Diseases Department, Federal University of Sao Paulo, São Paulo, Brazil.

PMID: 32541384
DOI: 10.1097/QAI.0000000000002418

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
CD4 Antigens / genetics*
Down-Regulation*
HEK293 Cells
HIV Infections
HIV-1 / genetics*
Humans
Membrane Proteins / genetics*
nef Gene Products, Human Immunodeficiency Virus / genetics*

Substances

CD4 Antigens
Membrane Proteins
SERINC5 protein, human
nef Gene Products, Human Immunodeficiency Virus
nef protein, Human immunodeficiency virus 1
nef protein, Human immunodeficiency virus 2