IL-1 family and Cutaneous Leishmaniasis: A poorly understood relationship

Ester Alves da Silva Amorim; Áquila Alcântara de França; Valéria Rêgo Alves Pereira; Maria Carolina Accioly Brelaz-de-Castro

doi:10.1016/j.cytogfr.2020.06.007

IL-1 family and Cutaneous Leishmaniasis: A poorly understood relationship

Cytokine Growth Factor Rev. 2021 Feb:57:85-92. doi: 10.1016/j.cytogfr.2020.06.007. Epub 2020 Jun 8.

Authors

Ester Alves da Silva Amorim¹, Áquila Alcântara de França², Valéria Rêgo Alves Pereira³, Maria Carolina Accioly Brelaz-de-Castro⁴

Affiliations

¹ Federal University of Pernambuco (UFPE), Academic Center of Vitória (CAV), Rua do Alto do Reservatório s/n, Bela Vista, Vitória de Santo Antão, Pernambuco, PE, 55608-680, Brazil; Oswaldo Cruz Pernambuco Foundation (Fiocruz/PE), Department of Immunology, Av. Moraes Rego, s/n - Cidade Universitária, 50670-420, Recife, Pernambuco, Brazil. Electronic address: esteralves1997@hotmail.com.
² Federal University of Pernambuco (UFPE), Academic Center of Vitória (CAV), Rua do Alto do Reservatório s/n, Bela Vista, Vitória de Santo Antão, Pernambuco, PE, 55608-680, Brazil; Oswaldo Cruz Pernambuco Foundation (Fiocruz/PE), Department of Immunology, Av. Moraes Rego, s/n - Cidade Universitária, 50670-420, Recife, Pernambuco, Brazil. Electronic address: aquilaalcf@gmail.com.
³ Oswaldo Cruz Pernambuco Foundation (Fiocruz/PE), Department of Immunology, Av. Moraes Rego, s/n - Cidade Universitária, 50670-420, Recife, Pernambuco, Brazil. Electronic address: valeriaph@gmail.com.
⁴ Federal University of Pernambuco (UFPE), Academic Center of Vitória (CAV), Rua do Alto do Reservatório s/n, Bela Vista, Vitória de Santo Antão, Pernambuco, PE, 55608-680, Brazil; Oswaldo Cruz Pernambuco Foundation (Fiocruz/PE), Department of Immunology, Av. Moraes Rego, s/n - Cidade Universitária, 50670-420, Recife, Pernambuco, Brazil. Electronic address: carolina.brelaz@gmail.com.

PMID: 32540132
DOI: 10.1016/j.cytogfr.2020.06.007

Abstract

The cytokines of the interleukin (IL) -1 family act in the initiation of an effective immune response in Leishmania infection, represented mainly by the T helper 1 (Th1) profile, in addition to being associated with disease exacerbation and controversial contributions in the Th2 responses. The family also includes members who self-regulate inflammation, such as antagonists and anti-inflammatory cytokines, most of which have not yet been studied in Cutaneous Leishmaniasis (CL) in humans. Here we summarize findings about what is known so far about the role of these cytokines in mice, the main study model, and in humans. We reinforce the importance of studies of these cytokines as new targets in the context of CL.

Keywords: Cutaneous leishmaniasis; Cytokines; IL-1 family; Immune response; Inflammation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytokines
Interleukin-1
Leishmaniasis, Cutaneous*
Mice
Th1 Cells

Substances

Cytokines
Interleukin-1