Extraction chromatography of 225Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

Mitchell T Friend; T Gannon Parker; Tara Mastren; Veronika Mocko; Mark Brugh; Eva R Birnbaum; Michael E Fassbender

doi:10.1016/j.chroma.2020.461219

Extraction chromatography of ²²⁵Ac and lanthanides on N,N-dioctyldiglycolamic acid /1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide solvent impregnated resin

J Chromatogr A. 2020 Aug 2:1624:461219. doi: 10.1016/j.chroma.2020.461219. Epub 2020 May 23.

Authors

Mitchell T Friend¹, T Gannon Parker¹, Tara Mastren², Veronika Mocko¹, Mark Brugh¹, Eva R Birnbaum¹, Michael E Fassbender³

Affiliations

¹ Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
² Nuclear Engineering Program, Department of Civil and Environmental Engineering, University of Utah, 110 Central Campus Drive, Suite 2000b, Salt Lake City, UT, 84112, USA; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
³ Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA. Electronic address: mifa@lanl.gov.

PMID: 32540068
DOI: 10.1016/j.chroma.2020.461219

Abstract

The alpha-emitter ²²⁵Ac (t_1/2 = 9.92 d) is currently under development for targeted alpha-particle therapy of cancer, and accelerator production of ²²⁵Ac via proton irradiation of thorium targets requires robust separations of ²²⁵Ac from chemically similar fission product lanthanides. Additionally, the lanthanide elements represent critical components in modern technologies, and radiolanthanides such as ¹⁴⁰Nd (t_1/2 = 3.37 d) also have potential application in the field of nuclear medicine. The ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][NTf₂]), combined with the diglycolamide extractant, N,N-dioctyldiglycolamic acid (DODGAA), was adsorbed on macroporous resin support to produce a solvent impregnated resin (SIR) that was investigated for separations of ²²⁵Ac and lanthanides. The equilibrium distribution coefficients (K_d) of the rare earth elements (Sc(III), Y(III), Ln(III)), ²²⁵Ac(III), Th(IV), and U(VI) on the prepared DODGAA/[Bmim][NTf₂]-SIR were determined from batch adsorption experiments in HCl and HNO₃ media. The DODGAA/[Bmim][NTf₂]-SIR exhibited preferential uptake of the heavier lanthanide elements while allowing for the separation of the lighter lanthanides. Column separations utilizing the DODGAA/[Bmim][NTf₂]-SIR were effective at separating the lighter lanthanides from each other, and separating ²²⁵Ac from a mixture of lanthanides, ²¹³Bi, and ²²⁵Ra without the need for additional complexing agents.

Keywords: Actinium-225; Extraction chromatography; Ionic liquid; Lanthanide separation; Solvent impregnated resin.

MeSH terms

Actinium / isolation & purification*
Chromatography, Ion Exchange / methods*
Glycolates / chemistry*
Imidazoles / chemistry*
Ionic Liquids / chemistry
Lanthanoid Series Elements / chemistry*
Lanthanoid Series Elements / isolation & purification
Porosity
Solvents / chemistry
Spectrophotometry, Atomic

Substances

1-butyl-3-methylimidazolium
Actinium-225
Glycolates
Imidazoles
Ionic Liquids
Lanthanoid Series Elements
N,N-dioctyldiglycol amic acid
Solvents
Actinium