Association between genetic variants at 9p21 locus with risk of breast cancer: A systematic review and meta-analysis

Hossein Abdeahad; Afsane Bahrami; Nikoo Saeedi; Mohammad Shabani; Milad Pezeshki; Majid Khazaei; Mojtaba Shafiee; Elnaz Ghorbani; Gordon A Ferns; Saman Soleimanpour; Farzad Rahmani; Atena Soleimani; Hamid Fiuji; Mikhail Ryzhikov; Amir Avan; Seyed Mahdi Hassanian

doi:10.1016/j.prp.2020.152987

Association between genetic variants at 9p21 locus with risk of breast cancer: A systematic review and meta-analysis

Pathol Res Pract. 2020 Jul;216(7):152987. doi: 10.1016/j.prp.2020.152987. Epub 2020 Apr 26.

Authors

Hossein Abdeahad¹, Afsane Bahrami², Nikoo Saeedi³, Mohammad Shabani⁴, Milad Pezeshki⁵, Majid Khazaei⁶, Mojtaba Shafiee⁷, Elnaz Ghorbani⁸, Gordon A Ferns⁹, Saman Soleimanpour⁸, Farzad Rahmani¹⁰, Atena Soleimani¹¹, Hamid Fiuji¹², Mikhail Ryzhikov¹³, Amir Avan¹⁴, Seyed Mahdi Hassanian¹⁵

Affiliations

¹ Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of nutrition and integrative physiology, University of Utah, Salt lake city, Utah, USA.
² Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
³ Student Research Committee, Islamic Azad University, Mashhad Branch, Mashhad, Iran.
⁴ Department of Medical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁵ Molecular Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.
⁶ Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 4Z2, Canada.
⁸ Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁹ Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH, UK.
¹⁰ Iranshahr Medical University, Iranshahr, Iran.
¹¹ Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
¹² Department of Biochemistry, Payame-Noor University, Mashhad, Iran.
¹³ Division of Pulmonary and Critical Care Medicine, Washington University, School of Medicine, Saint Louis, MO, USA.
¹⁴ Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
¹⁵ Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: hasanianmehrm@mums.ac.ir.

PMID: 32534702
DOI: 10.1016/j.prp.2020.152987

Abstract

Breast cancer (BC) is the most frequent tumor in women and genetic factors are among the main risk factors contributing to this malignancy. Chromosome 9p21 contains important regulatory non-coding RNAs and is associated with multiple malignancies including BC. The current meta-analysis aimed to investigate the association between genetic variants within the 9p21 locus and risk of breast cancer. A literature search was performed using PubMed, Web of Science, Embase, MEDLINE, Scopus and Clinical key databases. Nine studies containing 23,726 subjects were eligible for the final analysis and specific odds ratios (OR) and confidence intervals (95% CI) were evaluated to assess the strength of the associations. In the pooled analysis, there was an association between the genetic variations in 9p21 locus (CDKN2A/2B) with risk of breast cancer with a standard OR of 1.22 (95% CI: 1.04-1.45, P = 0.016; random-effects model), supporting the significance of this locus as a novel risk factor for breast cancer patients. In conclusion, our results showed that 9p21 region is positively associated with risk of BC and its polymorphisms may be a candidate marker for BC susceptibility.

Keywords: 9p21; Breast neoplasm; Carcinoma; Polymorphism; Risk factor.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Breast Neoplasms / genetics*
Chromosomes, Human, Pair 9 / genetics*
Female
Genetic Predisposition to Disease / genetics*
Humans
Polymorphism, Single Nucleotide