IgA Summons IgG to Take a Hit at HIV-1

Cell Host Microbe. 2020 Jun 10;27(6):854-856. doi: 10.1016/j.chom.2020.05.017.

Abstract

In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.

Publication types

  • Comment

MeSH terms

  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • HIV Antibodies
  • HIV-1 / immunology*
  • Humans
  • Immunoglobulin A
  • Immunoglobulin G
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2
  • Severe acute respiratory syndrome-related coronavirus*
  • Single-Domain Antibodies*

Substances

  • HIV Antibodies
  • Immunoglobulin A
  • Immunoglobulin G
  • Single-Domain Antibodies