Effects of a short-term increase in physical activity on arterial stiffness during hyperglycemia

Ryota Kobayashi; Kaori Sato; Toshihiko Takahashi; Kenji Asaki; Soichiro Iwanuma; Nobuyuki Ohashi; Takeo Hashiguchi

doi:10.3164/jcbn.19-69

Effects of a short-term increase in physical activity on arterial stiffness during hyperglycemia

J Clin Biochem Nutr. 2020 May;66(3):238-244. doi: 10.3164/jcbn.19-69. Epub 2020 Mar 6.

Authors

Ryota Kobayashi¹, Kaori Sato², Toshihiko Takahashi³, Kenji Asaki⁴, Soichiro Iwanuma⁵, Nobuyuki Ohashi⁵, Takeo Hashiguchi⁵

Affiliations

¹ Center for Fundamental Education, Teikyo University of Science, 2-2-1 Senju, Sakuragi, Adachi-ku, Tokyo 120-0045, Japan.
² College of Liberal Arts, International Christian University, 3-10-2 Osawa, Mitaka-shi, Tokyo 181-8585, Japan.
³ Adachi-ku Track and Field Association, 1-33-22 Yanaka, Adachi-ku, Tokyo 120-0006, Japan.
⁴ Department of Tokyo Judo Therapy, Teikyo University of Science, 2-2-1 Senju, Sakuragi, Adachi-ku, Tokyo 120-0045, Japan.
⁵ Department of School Education, Teikyo University of Science, 2-2-1 Senju, Sakuragi, Adachi-ku, Tokyo 120-0045, Japan.

Abstract

We examined the effects of increasing physical activity on arterial stiffness during hyperglycemia. Nineteen glucose-intolerant elderly participated in the study. We randomly assigned 10 participants to increase their daily activity in everyday life, regardless of the time or intensity, for 1 month (PAI group) (age, 74.6 ± 1.3 years; mean ± SE) and nine participants to maintain their level of activity (CON group) (age, 79.2 ± 2.1 years; mean ± SE). The 75-g oral glucose tolerance test was conducted in each participant in both groups before and after the start of the intervention to confirm glucose intolerance. Brachial-ankle pulse wave velocity and cardio-ankle vascular index significantly increased from baseline at 30, 60, and 90 min after the 75-g glucose ingestion after the intervention in the CON group (p<0.05), but not in the PAI group. Heart-brachial pulse wave velocity did not change compared to baseline after the 75-g glucose ingestion in either group and did not change from baseline at 30, 60, and 90 min after the 75-g glucose ingestion before and after the intervention in both groups. The present findings indicate that a short-term increase in physical activity suppresses the increase in arterial stiffness after glucose intake.

Keywords: arterial stiffness; blood glucose; blood pressure; glucose ingestion; increased physical activity.