Although research has identified dozens of behavioral and psychosocial strategies for boosting resilience in adults, little is known about the common underlying pathways. A comprehensive review of these strategies using an affective neuroscience approach indicates three distinct general routes to resilience: 1) down-regulating the negative (e.g., exposure, cognitive reappraisal) by reducing distress-related responses of the amygdala, hypothalamic-pituitary-adrenal axis, and autonomic nervous system; 2) up-regulating the positive (e.g., optimism, social connectedness) by activating mesostriatal reward pathways, which in turn can buffer the effects of stress; and 3) transcending the self (e.g., mindfulness, religious engagement) by reducing activation in the default mode network, a network associated with self-reflection, mind-wandering, and rumination. Some strategies (e.g., social support) can boost resilience via more than one pathway. Under- or over-stimulation of a pathway can result in vulnerability, such as over-stimulation of the reward pathway through substance abuse. This tripartite model of resilience-building is testable, accounts for a large body of data on adult resilience, and makes new predictions with implications for practice.
Keywords: Affective neuroscience; Amygdala; Default mode; Emotion regulation; Resilience; Reward; Stress; Well-being.
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