Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism

Mutat Res Genet Toxicol Environ Mutagen. 2020 May:853:503170. doi: 10.1016/j.mrgentox.2020.503170. Epub 2020 Mar 14.

Abstract

We examined possible early-effect biomarkers and polymorphisms of susceptibility in primary school children living near the Atoyac River in central México, which receives waste from multiple industries. We observed a significant increase in micronucleated reticulocytes associated with the oxidative stress index (OSI) and the OGG1 GG (S326C) genotype, and a significant decrease of reticulocytes carrying the transferrin receptor, inversely correlated with OSI.

Keywords: erythrocytes; transferrin receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Biomarkers / metabolism
  • Child
  • DNA Glycosylases / genetics*
  • Environmental Pollution / adverse effects*
  • Female
  • Genotype
  • Humans
  • Male
  • Micronucleus Tests / methods
  • Oxidative Stress / drug effects*
  • Polymorphism, Genetic / drug effects*
  • Reticulocytes / drug effects*

Substances

  • Biomarkers
  • DNA Glycosylases
  • oxoguanine glycosylase 1, human