Abstract
An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results have demonstrated that the cell membrane-like delivery system possessed an improved cellular uptake and favorable antitumor efficacy with reduced side-effects. This strategy provides a new effective platform in drug delivery for cancer chemotherapy.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / therapeutic use*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry
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Female
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Humans
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Liposomes / chemical synthesis
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Liposomes / chemistry
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Liposomes / therapeutic use*
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Mice, Inbred BALB C
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Neoplasms / drug therapy*
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Phosphatidylcholines / chemical synthesis
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Phosphatidylcholines / chemistry
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Phosphatidylcholines / therapeutic use*
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Podophyllotoxin / analogs & derivatives*
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Podophyllotoxin / chemical synthesis
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Podophyllotoxin / therapeutic use*
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Prodrugs / therapeutic use
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents
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Drug Carriers
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Liposomes
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Phosphatidylcholines
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Prodrugs
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Podophyllotoxin