Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9

J Antimicrob Chemother. 2020 Nov 1;75(11):3087-3095. doi: 10.1093/jac/dkaa205.

Abstract

The identification of the first mobile colistin resistance (MCR) gene, mcr-1, in 2015 triggered a rash of mcr screening reports. Subsequently, nine MCR-family genes and their variants have been described. However, a comprehensive overview concerning the epidemiology of the whole MCR family, which is essential for facilitating rational interventions against mcr dissemination, is lacking. Here, based on the National Database of Antibiotic Resistant Organisms and published studies, we have summarized the latest epidemiological characteristics of the mcr genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Colistin* / pharmacology
  • Drug Resistance, Bacterial / genetics
  • Escherichia coli
  • Escherichia coli Proteins* / genetics

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • MCR-1 protein, E coli
  • Colistin