MicroRNAs in hematopoietic stem cell aging

Daniëlle Gaby Luinenburg; Gerald de Haan

doi:10.1016/j.mad.2020.111281

MicroRNAs in hematopoietic stem cell aging

Mech Ageing Dev. 2020 Jul:189:111281. doi: 10.1016/j.mad.2020.111281. Epub 2020 Jun 5.

Authors

Daniëlle Gaby Luinenburg¹, Gerald de Haan²

Affiliations

¹ Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, 9700 AV Groningen, the Netherlands.
² Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, 9700 AV Groningen, the Netherlands. Electronic address: g.de.haan@umcg.nl.

PMID: 32512019
DOI: 10.1016/j.mad.2020.111281

Abstract

The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic factors that regulate quiescence, self-renewal and differentiation. MicroRNAs (miRs) have an indispensable role in the regulation of HSCs and have been shown to also regulate processes related to tissue aging in specific cell types. Here we discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.

Keywords: Aging; Hematopoietic stem cell; microRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / metabolism*
Animals
Cell Differentiation*
Cellular Senescence*
Hematopoietic Stem Cells / metabolism*
Humans
MicroRNAs / metabolism*

Substances

MicroRNAs