Subjective Cognitive Decline and Related Cognitive Deficits

Tong Si; Guoqiang Xing; Ying Han

doi:10.3389/fneur.2020.00247

Subjective Cognitive Decline and Related Cognitive Deficits

Front Neurol. 2020 May 19:11:247. doi: 10.3389/fneur.2020.00247. eCollection 2020.

Authors

Tong Si¹, Guoqiang Xing², Ying Han^{1

3

4}

Affiliations

¹ Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
² The Affiliated Hospital and the Second Clinical Medical College of North Sichuan Medical University, Nanchong Central Hospital, Nanchong, China.
³ National Clinical Research Center for Geriatric Disorders, Beijing, China.
⁴ Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China.

Abstract

Since late stage dementia, including Alzheimer's disease (AD), cannot be reversed by any available drugs, there is increasing research interest in the preclinical stage of AD, i.e., subjective cognitive decline (SCD). SCD is characterized by self-perceptive cognitive decline but is difficult to detect using objective tests. At SCD stage, the cognitive deficits can be more easily reversed compared to that of mild cognitive impairment (MCI) and AD only if accurate diagnosis of SCD and early intervention can be developed. In this paper, we review the recent progress of SCD research including current assessment tools, biomarkers, neuroimaging, intervention and expected prognosis, and the potential relevance to traumatic brain injury (TBI)-induced cognitive deficits.

Keywords: Alzheimer's disease; diagnosis; intervention; mild cognitive impairment; subjective cognitive decline; traumatic brain injury.

Publication types

Review