Synthesis and biological activity of a novel fungicide, flutianil

Masatoshi Hayashi; Yasuhiro Endo; Tomozo Komura; Sachi Kimura; Hisashi Oka

doi:10.1584/jpestics.D19-077

Synthesis and biological activity of a novel fungicide, flutianil

J Pestic Sci. 2020 May 20;45(2):105-108. doi: 10.1584/jpestics.D19-077.

Authors

Masatoshi Hayashi¹, Yasuhiro Endo², Tomozo Komura³, Sachi Kimura⁴, Hisashi Oka⁵

Affiliations

¹ Independent Researcher, Japan.
² OAT Agrio, Production Engineering Group, Production Control Division, Naruto, Tokushima 772-0021, Japan.
³ OAT Agrio, Regulatory Group, Research and Development Division, Naruto, Tokushima 772-0021, Japan.
⁴ OAT Agrio, Biological Science Group, Research and Development Division, Naruto, Tokushima 779-0301, Japan.
⁵ OAT Agrio, Research and Development Division, Naruto, Tokushima 779-0021, Japan.

Abstract

Flutianil was discovered as a novel fungicide chemically characterized as a cyano-methylene thiazolidine. This chemical showed particularly high fungicidal activities against powdery mildew on various crops. Optimization of the fungicidal performance of the series of synthesized chemicals finally led to the identification of flutianil, which could control powdery mildew diseases. In this report, details of the structure-activity relationships from the lead compound to flutianil are described.

Keywords: OK-5203; cyano-methylene thiazolidine; flutianil; fungicide; structure–activity relationship.

© Pesticide Science Society of Japan 2020. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License (https://creativecommons.org/licenses/by-nc-nd/4.0/).