Progressive Decline of the Glomerular Filtration Rate in HIV-infected Children Treated With Tenofovir Disoproxil Fumarate-based Regimens in West and Central Africa

Pediatr Infect Dis J. 2020 Aug;39(8):737-739. doi: 10.1097/INF.0000000000002733.

Abstract

A cross-sectional study of 358 HIV-1-infected children and adolescents living in Sub-Saharan Africa treated with tenofovir disoproxil fumarate-based regimens for a median of 1.5 interquartile range [0.6-3.1 years] showed a loss of glomerular filtration rate estimated to be 0.41 mL/min/1.73 m per month of treatment. In contrast, there was no decrease depending on the duration of the previous antiretroviral treatment.

Publication types

  • Multicenter Study
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Africa South of the Sahara
  • Africa, Central
  • Anti-HIV Agents / adverse effects*
  • Anti-HIV Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Glomerular Filtration Rate / drug effects*
  • HIV-1 / drug effects
  • Humans
  • Male
  • Tenofovir / adverse effects*
  • Tenofovir / therapeutic use*

Substances

  • Anti-HIV Agents
  • Tenofovir