Roles of F-18-Fluoro-2-Deoxy-Glucose PET/Computed Tomography Scans in the Management of Post-Transplant Lymphoproliferative Disease in Pediatric Patient

PET Clin. 2020 Jul;15(3):309-319. doi: 10.1016/j.cpet.2020.03.006.

Abstract

Post-transplant lymphoproliferative disease is a well-known complication in transplant recipients. Evaluating the extent and stage of disease is important for management and follow-up. As a combination of anatomic and functional imaging, PET/CT is a sensitive and specific tool to stage and detect occult disease compared with conventional imaging. PET/CT also has a role in monitoring treatment response. Although PET/CT has been shown to be potentially useful in adults, evidence in children is insufficient. This review provides an overview of the use of PET/CT in post-transplant lymphoproliferative disease, especially in pediatric patients.

Keywords: PET/CT; PTLD; Pediatrics.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Fluorodeoxyglucose F18*
  • Humans
  • Lymphoproliferative Disorders / diagnostic imaging*
  • Pediatrics / methods*
  • Positron Emission Tomography Computed Tomography / methods*
  • Postoperative Complications / diagnostic imaging*
  • Radiopharmaceuticals
  • Transplants*

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18