Histologic diagnosis of a case of anal duct carcinoma with cytological correlation and differential diagnoses

Ann Diagn Pathol. 2020 Aug:47:151535. doi: 10.1016/j.anndiagpath.2020.151535. Epub 2020 May 20.

Abstract

Anal duct carcinoma is an uncommon malignancy of the glands of the anal duct. This entity poses a diagnostic challenge, both clinically and histologically. This article describes histopathologic findings in a case of anal duct carcinoma, including the initial diagnosis on biopsy and subsequent cytology specimens. Additionally, differential diagnoses of this neoplasm are discussed. With a high index of suspicion, and attention to histological and immunohistochemical features, anal duct carcinoma can be accurately diagnosed both on biopsy and on cytology.

Keywords: Anal duct carcinoma; Biopsy; Cytology; Differential diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / diagnosis
  • Abdominal Pain / etiology
  • Anus Neoplasms / pathology*
  • Ascites / etiology
  • Ascites / pathology*
  • Biopsy / methods
  • Carcinoma, Ductal / complications
  • Carcinoma, Ductal / diagnosis*
  • Carcinoma, Ductal / metabolism
  • Constipation / diagnosis
  • Constipation / etiology
  • Cytodiagnosis / methods*
  • Diagnosis, Differential
  • Female
  • Hospice Care
  • Humans
  • Keratins / metabolism
  • Middle Aged
  • Paracentesis / methods
  • Peritoneal Neoplasms / diagnosis

Substances

  • Keratins