Severe Refractory Checkpoint Inhibitor-Related Hepatitis Reversed With Anti-Thymocyte Globulin and n-Acetylcysteine

Hepatology. 2020 Dec;72(6):2235-2238. doi: 10.1002/hep.31396. Epub 2020 Nov 21.

Authors

Douglas Motomura¹, Tara Baetz², Andrea Grin³, Jennifer A Flemming¹

Affiliations

¹ Department of Medicine, Queen's University, Kingston, Ontario, Canada.
² Department of Oncology, Queen's University, Kingston, Ontario, Canada.
³ Department of Pathology, Queen's University, Kingston, Ontario, Canada.

PMID: 32484945
DOI: 10.1002/hep.31396

No abstract available

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Acetylcysteine / therapeutic use*
Antilymphocyte Serum / therapeutic use*
Chemotherapy, Adjuvant / adverse effects
Chemotherapy, Adjuvant / methods
Drug Resistance
Drug Therapy, Combination / methods
Female
Glucocorticoids / therapeutic use
Hepatitis / diagnosis
Hepatitis / drug therapy*
Hepatitis / immunology
Humans
Immune Checkpoint Inhibitors / adverse effects*
Immunosuppressive Agents / therapeutic use*
Melanoma / immunology
Melanoma / secondary
Melanoma / therapy
Middle Aged
Severity of Illness Index
Skin Neoplasms / immunology
Skin Neoplasms / pathology
Skin Neoplasms / therapy
Treatment Outcome

Substances

Antilymphocyte Serum
Glucocorticoids
Immune Checkpoint Inhibitors
Immunosuppressive Agents
Acetylcysteine