Abstract
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.
Keywords:
asthma mechanisms; cytokine biology.
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Asthma / metabolism*
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Asthma / pathology
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Asthma / physiopathology
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Biopsy
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Bronchi / metabolism
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Bronchi / pathology
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Bronchoalveolar Lavage Fluid / chemistry
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Cross-Sectional Studies
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Cytokines / metabolism*
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Female
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Forced Expiratory Volume
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Humans
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Inflammation / metabolism
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Leukocyte Count
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Leukocytes / metabolism*
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Male
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Middle Aged
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Polymorphism, Single Nucleotide
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Respiratory Mucosa / metabolism
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Respiratory Mucosa / pathology
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Severity of Illness Index
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Sputum / cytology
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Sputum / metabolism*
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TNF-Related Apoptosis-Inducing Ligand / analysis
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TNF-Related Apoptosis-Inducing Ligand / genetics
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TNF-Related Apoptosis-Inducing Ligand / metabolism*
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Tumor Necrosis Factor Decoy Receptors / metabolism
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Vital Capacity
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Young Adult
Substances
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Cytokines
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TNF-Related Apoptosis-Inducing Ligand
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TNFSF10 protein, human
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Tumor Necrosis Factor Decoy Receptors