Objective: To investigate the fertility needs and outcome of pregnancy in patients with young breast cancer in China. Methods: A retrospective cross-sectional investigation was conducted on 374 young breast cancer women from Cancer Hospital, Chinese Academy of Medical Sciences. Young patients with breast cancer were defined as patients who got initial diagnosis of breast cancer at age no more than 40 years old. We conducted a questionnaire survey and collected clinical data from medical chart. Logistic regression model was used to analyze the possible factors influencing patients' fertility intention. Results: 308 young women with breast cancer completed questionnaires, and the response rate was 82.4%. 81 patients (26.3%) had fertility needs after diagnosis. Of them, 6 cases took active measures to preserve fertility. 72 patients (23.4%) received fertility counseling during treatment. 7 patients were successfully pregnant, including four cases who delivered normally. Multivariate logistic regression analysis showed that patients under 35 years old (OR=4.81), bachelor degree or above (OR=3.26), receiving breast-conserving surgery (OR=2.15) and childless patients (OR=3.03) were more likely to have fertility needs after diagnosis of breast cancer (all P<0.05). Conclusions: The fertility needs of young breast cancer women in China are gradually increasing. Healthcare providers associated with tumor patients should actively offer corresponding fertility consultation and individualized diagnosis and therapy plans for patients with fertility needs.
目的： 了解中国年轻乳腺癌患者的生育需求及怀孕和妊娠结局。 方法： 采用回顾性横断面调查方法，对在中国医学科学院肿瘤医院确诊时年龄≤40岁的374例乳腺癌患者进行问卷调查及临床资料收集。采用Logistic回归模型分析患者生育意愿的影响因素。 结果： 308例患者完成问卷调查，应答率为82.4%。81例(26.3%)患者在确诊乳腺癌后有生育需求，其中6例患者采取积极措施保留生育能力。72例(23.4%)患者在治疗过程中曾进行生育咨询。7例患者成功怀孕，其中4例患者正常分娩。多因素Logistic回归分析显示，年龄<35岁(OR＝4.81)、大学及以上学历(OR＝3.26)、行保乳手术(OR＝2.15)以及未生育者(OR＝3.03)在患病后更易有生育需求(均P<0.05)。 结论： 中国年轻乳腺癌女性生育需求日益增长，肿瘤相关医疗保健服务提供者应积极为有生育需求的患者提供相应的生育咨询及个体化诊疗。.
Keywords: Breast neoplasms; Fertility consultation; Fertility needs; Fertility protection treatment; Young women.