Previously unreported emergence of A265V substitution in the integrase gene in association with bictegravir virological failure

Int J Antimicrob Agents. 2020 Aug;56(2):106039. doi: 10.1016/j.ijantimicag.2020.106039. Epub 2020 May 29.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adenine / analogs & derivatives
  • Adenine / therapeutic use
  • Aged
  • Alanine
  • Amides
  • Cell Line
  • Drug Resistance, Viral / genetics*
  • Drug Therapy, Combination
  • Emtricitabine / therapeutic use
  • HEK293 Cells
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV Integrase / genetics*
  • HIV Integrase Inhibitors / therapeutic use*
  • HIV-1 / drug effects
  • HeLa Cells
  • Heterocyclic Compounds, 3-Ring
  • Heterocyclic Compounds, 4 or More Rings / therapeutic use*
  • Humans
  • Male
  • Mutation*
  • Piperazines
  • Pyridones
  • Tenofovir / analogs & derivatives
  • Treatment Failure

Substances

  • Amides
  • HIV Integrase Inhibitors
  • Heterocyclic Compounds, 3-Ring
  • Heterocyclic Compounds, 4 or More Rings
  • Piperazines
  • Pyridones
  • bictegravir
  • Tenofovir
  • HIV Integrase
  • tenofovir alafenamide
  • Emtricitabine
  • Adenine
  • Alanine