Gut Microbiota Features on Nursing Home Admission Are Associated With Subsequent Acquisition of Antibiotic-resistant Organism Colonization

Joyce Wang; Marco Cassone; Kristen Gibson; Bonnie Lansing; Lona Mody; Evan S Snitkin; Krishna Rao

doi:10.1093/cid/ciaa662

Gut Microbiota Features on Nursing Home Admission Are Associated With Subsequent Acquisition of Antibiotic-resistant Organism Colonization

Clin Infect Dis. 2020 Dec 15;71(12):3244-3247. doi: 10.1093/cid/ciaa662.

Authors

Joyce Wang¹, Marco Cassone², Kristen Gibson², Bonnie Lansing², Lona Mody^{2

3}, Evan S Snitkin^{1

4

5}, Krishna Rao⁵

Affiliations

¹ Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
² Division of Geriatrics and Palliative Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
³ Geriatric Research Education and Clinical Center, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.
⁴ Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
⁵ Division of Infectious Diseases, Department of Medicine, University of Michigan, Medical School, Ann Arbor, Michigan, USA.

Abstract

Nursing home (NH) patients often acquire colonization with antibiotic-resistant organisms (AROs). We show that patients exposed to broad-spectrum antibiotics during previous hospitalizations have elevated enterococcal relative abundances on NH admission and higher risk of subsequent ARO acquisition. Our findings suggest that interventions preventing ARO spread should extend beyond NH doors.

Keywords: antibiotic exposure; antibiotic-resistant organisms; genomic epidemiology; intestinal microbiota; skilled nursing facilities.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Anti-Bacterial Agents* / pharmacology
Anti-Bacterial Agents* / therapeutic use
Gastrointestinal Microbiome*
Hospitalization
Humans
Nursing Homes
Skilled Nursing Facilities

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding