Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis

Drew Blasco; Saige William Stortz; Margaux Marie-Rose Grivel; Gabriella A Dishy; Shana S Samuel; David Pilla; Francesca M Crump; Sarah A Lieff; Jourdan Williams; Phetsamone Phoummavong; Xufei Guo; Gary Brucato; Ragy R Girgis; Lawrence H Yang

doi:10.1111/eip.12983

Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis

Early Interv Psychiatry. 2021 Jun;15(3):742-745. doi: 10.1111/eip.12983. Epub 2020 Jun 1.

Authors

Drew Blasco¹, Saige William Stortz^{2

3}, Margaux Marie-Rose Grivel¹, Gabriella A Dishy^{2

4}, Shana S Samuel^{2

5}, David Pilla^{2

6}, Francesca M Crump^{7

8}, Sarah A Lieff¹, Jourdan Williams², Phetsamone Phoummavong⁹, Xufei Guo², Gary Brucato¹⁰, Ragy R Girgis¹¹, Lawrence H Yang^{1

12}

Affiliations

¹ School of Global Public Health, New York University, New York, New York, USA.
² Clinical and Counseling Department, Teachers College, Columbia University, New York, New York, USA.
³ Psychology Department, The Graduate Center at the City University of New York, New York, New York, USA.
⁴ Department of Translational Imaging, New York State Psychiatric Institute, New York, New York, USA.
⁵ Clinical Psychology at Queens College, The Graduate Center at the City University of New York, Queens, New York, USA.
⁶ Department of Counseling and Counseling Psychology, Graduate School of Education, Fordham University, New York, New York, USA.
⁷ Center of Prevention and Evaluation, New York State Psychiatric Institute, New York, New York, USA.
⁸ Department of Psychology, Rowan University, Glassboro, New Jersey, USA.
⁹ New York University, New York, New York, USA.
¹⁰ Columbia University Irving Medical Center and New York State Psychiatric Institute, New York, New York, USA.
¹¹ College of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, New York, USA.
¹² Mailman School of Public Health, Department of Epidemiology, Columbia University, New York, New York, USA.

Abstract

Aim: Fuelled by genomics advances, recent emphasis on the concept of "precision medicine," and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive possible benefits of genetic testing to inform future stakeholder education efforts.

Methods: Semistructured interviews were completed with 20 participants who met CHR criteria. Coding for genetic optimism was completed.

Results: Participants endorsed many conceptualizations of the link between genetics, the development of psychosis, and the benefits of genetic testing. Specifically, themes emerged surrounding how genetic testing may lead to greater genetic knowledge and tailored treatment.

Conclusions: Our results demonstrate that CHR participants generally endorse several precision psychiatry concepts, including how genetic testing may lead to tailored treatment advances. This knowledge may aid development of best communication practices regarding forthcoming genetic advances in diagnosis and treatment among CHR.

Keywords: clinical high-risk; genetic optimism; genetic testing; precision medicine; psychotic disorders.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Genetic Testing
Humans
Optimism
Psychiatry*
Psychotic Disorders* / diagnosis
Psychotic Disorders* / genetics

Abstract

Publication types

MeSH terms

Grants and funding