Plasma balls are droplets of deconfined plasma surrounded by a confining vacuum. We present the first holographic simulation of their real-time evolution via the dynamics of localized, finite-energy black holes in the five-dimensional anti-de Sitter (AdS) soliton background. The dual gauge theory is four-dimensional N=4 super Yang-Mills theory compactified on a circle with supersymmetry-breaking boundary conditions. We consider horizonless initial data sourced by a massless scalar field. Prompt scalar field collapse produces an excited black hole at the bottom of the geometry together with gravitational and scalar radiation. The radiation disperses to infinity in the noncompact directions and corresponds to particle production in the dual gauge theory. The black hole evolves toward the dual of an equilibrium plasma ball on a time scale longer than naively expected. This feature is a direct consequence of confinement and is caused by long-lived, periodic disturbances bouncing between the bottom of the AdS soliton and the AdS boundary.