Highlights of the 12th International Bordetella Symposium

Camille Locht; Nicholas H Carbonetti; James D Cherry; F Heath Damron; Kathryn M Edwards; Rachel Fernandez; Eric T Harvill; Daniela Hozbor; Kingston H G Mills; Maria Eugenia Rodriguez; Françoise Mascart

doi:10.1093/cid/ciaa651

Highlights of the 12th International Bordetella Symposium

Clin Infect Dis. 2020 Dec 3;71(9):2521-2526. doi: 10.1093/cid/ciaa651.

Authors

Affiliations

¹ Université Lille, Centre National de la Recherche Scientifique, Inserm, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1019, Unité Mixte de Recherche 8204, Center for Infection and Immunity of Lille, Lille, France.
² Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
³ David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁴ Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
⁵ Vaccine Development Center at West Virginia University Health Science Center, West Virginia University, Morgantown, West Virginia, USA.
⁶ Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
⁷ Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
⁸ Department of Infectious Diseases, College of Veterinary Sciences, University of Georgia, Athens, Georgia, USA.
⁹ Laboratorio VacSal, Instituto de Biotecnología y Biología Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Cientificas y Técnicas, La Plata, Argentina.
¹⁰ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
¹¹ Centro de Investigacion y Desarrollo en Fermentaciones Industriales, Consejo Nacional de Investigaciones Cientificas y Técnicas, La Plata, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
¹² Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles, Brussels, Belgium.

Abstract

To commemorate the 100th anniversary of the Nobel prize being awarded to Jules Bordet, the discoverer of Bordetella pertussis, the 12th International Bordetella Symposium was held from 9 to 12 April 2019 at the Université Libre de Bruxelles, where Jules Bordet studied and was Professor of Microbiology. The symposium attracted more than 300 Bordetella experts from 34 countries. They discussed the latest epidemiologic data and clinical aspects of pertussis, Bordetella biology and pathogenesis, immunology and vaccine development, and genomics and evolution. Advanced technological and methodological tools provided novel insights into the genomic diversity of Bordetella and a better understanding of pertussis disease and vaccine performance. New molecular approaches revealed previously unrecognized complexity of virulence gene regulation. Innovative insights into the immune responses to infection by Bordetella resulted in the development of new vaccine candidates. Such discoveries will aid in the design of more effective approaches to control pertussis and other Bordetella-related diseases.

Keywords: Bordetella; Bordetella genomics; pertussis epidemiology; pertussis vaccines; whooping cough.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Bordetella pertussis* / genetics
Genomics
Humans
Pertussis Vaccine
Virulence
Whooping Cough* / epidemiology

Substances

Pertussis Vaccine

Abstract

Publication types

MeSH terms

Substances

Grants and funding