Immune checkpoint inhibitors (ICI) have emerged as an important treatment strategy in lung cancer in recent years. Implementation and approval status of each approved ICI will be presented by summarizing the most important phase III studies of nivolumab, pembrolizumab, atezolizumab and durvalumab. ICI are used as mono- or combination therapy with chemotherapy according to programmed cell death 1 ligand 1 (PD-L1) status and therapy line.
Keywords: Immunotherapy; Non-small cell lung cancer; Programmed cell death 1 ligand 1 (PD-L1); Small cell lung cancer; Tumor mutational burden.