Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases

Clin Immunol. 2020 Aug:217:108480. doi: 10.1016/j.clim.2020.108480. Epub 2020 May 24.

Authors

Aristo Vojdani¹, Datis Kharrazian²

Affiliations

¹ Immunosciences Lab, Inc, 822 S. Robertson Blvd, Ste. 312, Los Angeles, CA 90035, USA; Department of Preventive Medicine, Loma Linda University, Loma Linda, CA 92350, USA. Electronic address: drari@msn.com.
² Department of Preventive Medicine, Loma Linda University, Loma Linda, CA 92350, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA. Electronic address: datis56@gmail.com.

No abstract available

Publication types

Letter

MeSH terms

Antibodies, Viral / chemistry
Antibodies, Viral / genetics
Autoantibodies / chemistry
Autoantibodies / genetics
Autoantibodies / immunology*
Autoantigens / chemistry
Autoantigens / genetics
Autoantigens / immunology*
Autoimmune Diseases / epidemiology*
Autoimmune Diseases / etiology
Autoimmune Diseases / immunology
Autoimmune Diseases / virology
Autoimmunity
Betacoronavirus / immunology*
Betacoronavirus / pathogenicity
COVID-19
COVID-19 Vaccines
Coronavirus Infections / epidemiology*
Coronavirus Infections / immunology
Coronavirus Infections / prevention & control
Coronavirus Infections / virology
Coronavirus Nucleocapsid Proteins
Cross Reactions
Gene Expression
Host-Pathogen Interactions / genetics
Host-Pathogen Interactions / immunology
Humans
Immunity, Innate
Nucleocapsid Proteins / chemistry
Nucleocapsid Proteins / genetics
Nucleocapsid Proteins / immunology*
Pandemics* / prevention & control
Phosphoproteins
Pneumonia, Viral / epidemiology*
Pneumonia, Viral / immunology
Pneumonia, Viral / prevention & control
Pneumonia, Viral / virology
Pulmonary Surfactant-Associated Proteins / antagonists & inhibitors
Pulmonary Surfactant-Associated Proteins / genetics
Pulmonary Surfactant-Associated Proteins / immunology
SARS-CoV-2
Spike Glycoprotein, Coronavirus / chemistry
Spike Glycoprotein, Coronavirus / genetics
Spike Glycoprotein, Coronavirus / immunology*
Viral Vaccines / adverse effects
Viral Vaccines / biosynthesis

Substances

Antibodies, Viral
Autoantibodies
Autoantigens
COVID-19 Vaccines
Coronavirus Nucleocapsid Proteins
Nucleocapsid Proteins
Phosphoproteins
Pulmonary Surfactant-Associated Proteins
Spike Glycoprotein, Coronavirus
Viral Vaccines
nucleocapsid phosphoprotein, SARS-CoV-2
spike protein, SARS-CoV-2