Lipid in Renal Carcinoma: Queen Bee to Target?

Trends Cancer. 2020 Jun;6(6):448-450. doi: 10.1016/j.trecan.2020.02.017. Epub 2020 Mar 17.

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

Keywords: CPT1A; HIF; ccRCC; clear cell renal cell carcinoma; hypoxia; lipid metabolism.

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Carcinoma, Renal Cell / drug therapy*
  • Carcinoma, Renal Cell / genetics
  • Carcinoma, Renal Cell / pathology
  • Carnitine O-Palmitoyltransferase / antagonists & inhibitors*
  • Carnitine O-Palmitoyltransferase / metabolism
  • Fatty Acids / metabolism
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Kidney Neoplasms / drug therapy*
  • Kidney Neoplasms / genetics
  • Kidney Neoplasms / pathology
  • Lipid Droplets / metabolism
  • Lipid Metabolism / drug effects*
  • Lipid Metabolism / genetics
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Mutation
  • Oxidation-Reduction / drug effects
  • Peroxisomes / drug effects
  • Peroxisomes / metabolism
  • Proteolysis
  • Tumor Hypoxia / genetics
  • Von Hippel-Lindau Tumor Suppressor Protein / genetics
  • Von Hippel-Lindau Tumor Suppressor Protein / metabolism

Substances

  • Antineoplastic Agents
  • Basic Helix-Loop-Helix Transcription Factors
  • Fatty Acids
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • endothelial PAS domain-containing protein 1
  • CPT1A protein, human
  • Carnitine O-Palmitoyltransferase
  • Von Hippel-Lindau Tumor Suppressor Protein
  • VHL protein, human