Novel multiwalled carbon nanotubes/ Fe-Co doped titanate nanotubes nanocomposite (MWCNTs/Fe-Co doped TNTs) facilitated the charge transfer and enhanced sensitivity and selectivity. Herein, three novel modified carbon paste sensors (CPSs) based on MWCNTs (sensor I), Fe-Co doped TNTs (sensor II) and MWCNTs/Fe-Co doped TNTs composite (sensor III) were fabricated for a simple, low cost and high accuracy electrochemical method for the potentiometric determination of sulpiride (SLP). The sensors exhibited excellent Nernstian slopes 57.1 ± 0.4, 56 ± 0.5 and 58.8 ± 0.2 mV decade-1 with detection limits (DL) 7.6 × 10-7, 1.58 × 10-6 and 8.7 × 10-8 mol L-1, quantification limits (QL) 2.5 × 10-6, 5.2 × 10-6 and 2.9 × 10-7 mol L-1 for a long lifetime 20, 18, and 25 weeks for sensors (I), (II), and (III), respectively. The modified sensor (III) was applicable by measuring the concentration of spiked SLP in pure solutions, pharmaceutical products, human urine, and real water samples. The proposed method can be used as an important analytical tool in the quality control of the pharmaceutical industry.