Patient health questionnaire-15 (PHQ-15) to distinguish bipolar II disorder from major depressive disorder

Da-Liang Sun; Qing-He Liu; Mei-Juan Li; Yuan Yang; Ran Zhang; Min Li; Si-Ying Xiang; Jian-Hua Chen

doi:10.1016/j.psychres.2020.113026

Patient health questionnaire-15 (PHQ-15) to distinguish bipolar II disorder from major depressive disorder

Psychiatry Res. 2020 Aug:290:113026. doi: 10.1016/j.psychres.2020.113026. Epub 2020 May 17.

Authors

Da-Liang Sun¹, Qing-He Liu¹, Mei-Juan Li¹, Yuan Yang¹, Ran Zhang¹, Min Li¹, Si-Ying Xiang², Jian-Hua Chen³

Affiliations

¹ Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health Center, Tianjin 300222, P.R. China.
² Shanghai Clinical Research Center for Mental Health, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, P.R. China. Electronic address: xiangsiying@sjtu.edu.cn.
³ Shanghai Clinical Research Center for Mental Health, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, P.R. China; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK. Electronic address: chenjhv@smhc.org.cn.

PMID: 32450414
DOI: 10.1016/j.psychres.2020.113026

Abstract

A sequential-recruited clinical trial has been conducted to assess capacity of Patient Health Questionnaire-15 (PHQ-15) in distinguishing bipolar II disorder from major depressive disorder. A total of 73 patients (49 BD-II depression patients) filled sociodemographic characteristics, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 Questionnaire (GAD-7), and PHQ-15. Sum score of PHQ-15 showed statistically significant difference in the two groups (t-test, P = 0.027). The area under the curve was 0.663 (P = 0.025), and the specificity was 0.75 at sum score of 13. Patients with BD-II depression has more somatic symptoms than MDD, and PHQ-15 might be used for identification.

Keywords: Bipolar disorder; Major depressive disorder; Patient health questionnaire-15.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bipolar Disorder / diagnosis*
Bipolar Disorder / psychology
Depressive Disorder, Major / diagnosis*
Depressive Disorder, Major / psychology
Female
Humans
Male
Middle Aged
Patient Health Questionnaire / standards*
Psychometrics
Sensitivity and Specificity
Somatoform Disorders / diagnosis*
Somatoform Disorders / psychology
Surveys and Questionnaires