Dendritic cell-mediated cancer immunotherapy with Ecklonia cava fucoidan

Hae-Bin Park; Juyoung Hwang; Seong-Min Lim; Wei Zhang; Jun-O Jin

doi:10.1016/j.ijbiomac.2020.05.160

Dendritic cell-mediated cancer immunotherapy with Ecklonia cava fucoidan

Int J Biol Macromol. 2020 Sep 15:159:941-947. doi: 10.1016/j.ijbiomac.2020.05.160. Epub 2020 May 21.

Authors

Hae-Bin Park¹, Juyoung Hwang¹, Seong-Min Lim², Wei Zhang³, Jun-O Jin⁴

Affiliations

¹ Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea.
² Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea.
³ Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China.
⁴ Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea. Electronic address: jinjo@yu.ac.kr.

PMID: 32446894
DOI: 10.1016/j.ijbiomac.2020.05.160

Abstract

Fucoidan is known to exert immunomodulatory effects in animals and humans. Here, we extracted fucoidan from Ecklonia cava (ECF) and evaluated its immunostimulatory and anticancer activities in mice. Treatment with ECF resulted in the activation of bone marrow-derived dendritic cells (BMDCs) in vitro and splenic DCs in vivo. Moreover, the combination of ECF and ovalbumin (OVA) promoted OVA-specific T cell proliferation and cytokine production, which consequently suppressed B16-OVA tumor growth in vivo. The combination treatment with ECF and carcinoma self-antigen resulted in the inhibition of the growth of CT-26 carcinoma in mice through carcinoma antigen-specific immunity. Thus, ECF could function as an adjuvant for the induction of anticancer immunity.

Keywords: Anti-cancer; Dendritic cell; Ecklonia cava Fucoidan.

MeSH terms

Animals
Antigens, Neoplasm / immunology
Cytokines / metabolism
Dendritic Cells / drug effects*
Dendritic Cells / immunology*
Dendritic Cells / metabolism
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Humans
Immunotherapy* / methods
Melanoma, Experimental
Mice
Mice, Transgenic
Neoplasms / etiology*
Neoplasms / metabolism*
Neoplasms / therapy
Phaeophyceae / chemistry*
Polysaccharides / pharmacology*
Spectroscopy, Fourier Transform Infrared
Treatment Outcome

Substances

Antigens, Neoplasm
Cytokines
Polysaccharides
fucoidan