Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

Pascal Loyer; Janeen H Trembley

doi:10.1016/j.semcdb.2020.04.016

Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

Semin Cell Dev Biol. 2020 Nov:107:36-45. doi: 10.1016/j.semcdb.2020.04.016. Epub 2020 May 20.

Authors

Pascal Loyer¹, Janeen H Trembley²

Affiliations

¹ INSERM, INRAE, Univ Rennes, NuMeCan, Nutrition Metabolisms and Cancer, Rennes, France. Electronic address: pascal.loyer@univ-rennes1.fr.
² Research Service, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: trem0005@umn.edu.

PMID: 32446654
DOI: 10.1016/j.semcdb.2020.04.016

Abstract

Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin complexes recently identified, as well as "canonical" CDK/Cyclin complexes regulating cell cycle, are implicated in the regulation of gene expression via the phosphorylation of key components of the transcription and pre-mRNA processing machineries. In this review, we summarize the role of CDK/cyclin-dependent phosphorylation in the regulation of transcription and RNA splicing and highlight recent findings that indicate the involvement of CDK11/cyclin L complexes at the cross-roads of cell cycle, transcription and RNA splicing. Finally, we discuss the potential of CDK11 and Cyclins L as therapeutic targets in cancer.

Keywords: CCNL1; CCNL2; CDK11; Cell Cycle; Cyclin L; Transcription; cancer; pre-mRNA splicing.

Publication types

Review

MeSH terms

Amino Acid Sequence
Animals
Cell Cycle / genetics*
Cyclin-Dependent Kinases / metabolism*
Cyclins / chemistry
Cyclins / metabolism*
Humans
RNA Precursors / genetics*
RNA Precursors / metabolism
RNA Splicing / genetics*
Transcription, Genetic*

Substances

Cyclins
RNA Precursors
Cyclin-Dependent Kinases