Use of Organs for Heart Transplantation after Rescue Allocation: Comparison of Outcome with Regular Allocated High Urgent Recipients

Thorac Cardiovasc Surg. 2021 Sep;69(6):497-503. doi: 10.1055/s-0040-1710053. Epub 2020 May 22.

Abstract

Background: The number of patients waiting for heart transplantation (HTx) is exceeding the number of actual transplants. Subsequently, waiting times are increasing. One possible solution may be an increased acceptance of organs after rescue allocation. These organs had been rejected by at least three consecutive transplant centers due to medical reasons.

Methods: Between October 2010 and July 2019, a total of 139 patients underwent HTx in our department. Seventy (50.4%) of the 139 patients were transplanted with high urgency (HU) status and regular allocation (HU group); the remaining received organs without HU listing after rescue allocation (elective group, n = 69).

Results: Donor parameters were comparable between the groups. Thirty-day mortality was comparable between HU patients (11.4%) and rescue allocation (12.1%). Primary graft dysfunction with extracorporeal life support occurred in 26.9% of the elective group with rescue allocated organs, which was not inferior to the regular allocated organs (HU group: 35.7%). No significant differences were observed regarding the incidence of common perioperative complications as well as morbidity and mortality during 1-year follow-up.

Conclusions: Our data support the use of hearts after rescue allocation for elective transplantation of patients without HU status. We could show that patients with rescue allocated organs showed no significant disadvantages in the early perioperative morbidity and mortality as well at 1-year follow-up.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Clinical Decision-Making
  • Donor Selection*
  • Extracorporeal Membrane Oxygenation
  • Female
  • Heart Transplantation* / adverse effects
  • Heart Transplantation* / mortality
  • Humans
  • Male
  • Middle Aged
  • Primary Graft Dysfunction / etiology
  • Primary Graft Dysfunction / physiopathology
  • Primary Graft Dysfunction / therapy
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Tissue Donors / supply & distribution*
  • Treatment Outcome
  • Waiting Lists