Eosinophilic fasciitis associated with generalized morphea and IgA nephropathy

Dermatol Ther. 2020 Jul;33(4):e13641. doi: 10.1111/dth.13641. Epub 2020 Jun 20.

Abstract

Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by increased peripheral blood eosinophils and diffuse fasciitis, generalized morphea (GM) is a subtype of localized scleroderma, and IgA nephropathy is a chronic glomerulonephritis caused by abnormal deposition of IgA in the mesangial area of the glomeruli. We describe a 49-year-old male patient with hard skin, cutaneous hyperpigmentation, and proteinuria. The patient had suffered from a long disease course of hard skin, while urine protein was newly detected. Finally, the clinical presentation and physical examination, limb MRI, skin biopsy, and renal biopsy confirmed the diagnosis of eosinophilic fasciitis associated with generalized morphea and IgA nephropathy. This case is the first report of EF associated with GM and IgA nephropathy.

Keywords: IgA nephropathy; eosinophilic fasciitis (EF); generalized morphea (GM).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Eosinophilia* / complications
  • Eosinophilia* / diagnosis
  • Fasciitis* / complications
  • Fasciitis* / diagnosis
  • Glomerulonephritis, IGA* / complications
  • Glomerulonephritis, IGA* / diagnosis
  • Humans
  • Male
  • Middle Aged
  • Scleroderma, Localized* / complications
  • Scleroderma, Localized* / diagnosis

Supplementary concepts

  • Eosinophilic Fasciitis