The influence of cobalt manganese ferrite nanoparticles (Co0.5Mn0.5Fe2O4) on reduction of hazardous effects of vanadate in adult rats

Mohamed M Rezk; Abdelghaffar S Dhmees; Mahmoud O Abd El-Magied; El-Sayed A Manaa; Hassan S El-Gendy

doi:10.1093/toxres/tfaa007

The influence of cobalt manganese ferrite nanoparticles (Co_0.5Mn_0.5Fe₂O₄) on reduction of hazardous effects of vanadate in adult rats

Toxicol Res (Camb). 2020 Apr 20;9(2):81-90. doi: 10.1093/toxres/tfaa007. eCollection 2020 Apr.

Authors

Mohamed M Rezk¹, Abdelghaffar S Dhmees², Mahmoud O Abd El-Magied¹, El-Sayed A Manaa¹, Hassan S El-Gendy¹

Affiliations

¹ Isotopes Department, Nuclear Materials Authority, P.O. Box 530, El Maadi, Cairo 11936, Egypt.
² Department of Analysis and Evaluation, Egyptian Petroleum Research Institute, 11727, Cairo, Egypt.

Abstract

Effect of cobalt manganese ferrite nanoparticles (M-NPs) (Co_0.5Mn_0.5Fe₂O₄) on vanadium hazards was assessment in the present study. Four groups of adult male albino rats [control group and three variably treated groups with ammonium metavanadate accompanied with or without cobalt M-NPs] were studied. The oral administration of ammonium metavanadate (Am.V) (20 mg/kg b.wt.) demonstrated the facility of vanadium to distribute and accumulate in the distinctive body organs and ordered as kidney > liver > lung > brain > spleen. Also, Am.V administration induce a significant disturbance in many physiological parameters (RBS, cholesterol, triglyceride, aspartate transaminase, alanine transaminase, Alb., bilirubin, Alk.Ph., urea, creat., Hb%, red blood cell count and packed cell volume) which might be expected to the liberation of free radicals according to the vanadium intoxication or its ability to disturb many body metabolisms. On the other hand, the intraperitoneal administration of 5% M-NPs in parallel with Am.V orally administration showed the ability of M-NPs to reduce Am.V dangerous impacts, which might be resulted from the essentiality of M-NPs metals to the body metabolism and to its free radicals scavenging properties. So, M-NPs could reduce Am.V hazardous effects.

Keywords: hematology; kidney; liver; nanoparticles; rat; vanadate.