SUMOylation in atherosclerosis

Yi-Zhang Liu; Xuan Xiao; Chu-Ting Hu; Yuan Dai; Shun-Lin Qu; Liang Huang; Chi Zhang

doi:10.1016/j.cca.2020.05.033

SUMOylation in atherosclerosis

Clin Chim Acta. 2020 Sep:508:228-233. doi: 10.1016/j.cca.2020.05.033. Epub 2020 May 18.

Authors

Yi-Zhang Liu¹, Xuan Xiao¹, Chu-Ting Hu², Yuan Dai³, Shun-Lin Qu⁴, Liang Huang⁵, Chi Zhang⁶

Affiliations

¹ Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Research Lab for Clinical & Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Departments of Clinical Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China.
² Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Research Lab for Clinical & Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Departments of Medical Laboratary, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China.
³ Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Research Lab for Clinical & Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Departments of Anaesthesiology, Chuanshan College, University of South China, Hengyang, Hunan 421001, People's Republic of China.
⁴ Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China.
⁵ Research Lab for Clinical & Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China. Electronic address: huangliang0530@hotmail.com.
⁶ Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China. Electronic address: zhangchi9966@hotmail.com.

PMID: 32439557
DOI: 10.1016/j.cca.2020.05.033

Abstract

Atherosclerosis (AS) is the pathophysiologic basis of many cardiovascular diseases. A number of studies have shown that post-translational modification (PTM) contributes to the initiation and progression of AS. For example, recent studies found that SUMOylation, ie, small ubiquitin-like modifier (SUMO) conjugation to target substrate proteins, was involved in AS. This PTM appears related to endothelial cell dysfunction (ECD), dyslipidemia and vascular smooth muscle cell (VSMC) proliferation. This review focuses on the molecular effects of SUMOylation in the initiation and progression of AS, including ECD, dyslipidemia and VSMC proliferation to better understand this pathologic process.

Keywords: Atherosclerosis; Dyslipidemia; Endothelial cell; SUMO; Vascular smooth muscle cells.

Publication types

Review

MeSH terms

Atherosclerosis*
Endothelial Cells / metabolism
Humans
Protein Processing, Post-Translational
Small Ubiquitin-Related Modifier Proteins / genetics
Small Ubiquitin-Related Modifier Proteins / metabolism
Sumoylation*

Substances

Small Ubiquitin-Related Modifier Proteins