Lung cancer is the most common malignant tumor in the world with the highest incidence of deaths. In recent years, the treatment of lung cancer has made a significant breakthrough. However, as the tumor progresses, lung cancer cells inevitably acquire resistance and the efficacy of the treatment are greatly reduced. P21 protein plays a dual role in tumors, which not only regulates the cell cycle, induces apoptosis, inhibits cell proliferation, but also protects cells against apoptosis and promotes tumor cell resistance. This article reviews the research on P21 and lung cancer resistance, to provide new ideas for individualized treatment of lung cancer and overcoming lung cancer resistance.
【中文题目：P21参与肺癌耐药的研究进展】 【中文摘要：肺癌是全球发生率最高和死亡人数最多的恶性肿瘤。近些年肺癌的治疗取得重大突破，但是随着病情的进展，患者不可避免地出现耐药，药物疗效大大降低。P21蛋白是一种在肿瘤中发挥双重作用的蛋白，既能调控细胞周期、诱导细胞凋亡、抑制细胞增殖，也能保护细胞抵抗凋亡，在肿瘤细胞耐药中发挥重要作用。本文就P21与肺癌耐药及其相关研究进行综述，为临床肺癌的个体化治疗与克服肺癌耐药提供新的思路。】 【中文关键词：肺肿瘤；P21；耐药】.
Keywords: Drug resistance; Lung neoplasms; P21.