Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient

Baofeng Feng; Jun Ma; Asiamah Ernest Amponsah; Ruiyun Guo; Desheng Kong; Jingjing He; Yawen Jiang; Wei Zhang; Zhanchi Zhang; Yongzhou Song; Sanbing Shen; Timothy O'Brien; Huixian Cui

doi:10.1016/j.scr.2020.101841

Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient

Stem Cell Res. 2020 May:45:101841. doi: 10.1016/j.scr.2020.101841. Epub 2020 May 8.

Authors

Affiliations

¹ Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China.
² Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China.
³ Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; The Second Hospital of Hebei Medical University, Hebei Province 050017, China.
⁴ Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Regenerative Medicine Institute, National University of Ireland Galway, Galway, Ireland.
⁵ Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China. Electronic address: huixiancuihmu@163.com.

PMID: 32434130
DOI: 10.1016/j.scr.2020.101841

Abstract

Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 60-year-old female diagnosed with sporadic amyotrophic lateral sclerosis (sALS). The iPSCs shared the same karyotype with the parent PBMCs, expressed pluripotency stem cell markers, and demonstrated trilineage differentiation potential. This cell line could serve as an ideal model to investigate the mechanisms underlying amyotrophic lateral sclerosis (ALS).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyotrophic Lateral Sclerosis* / genetics
Cell Differentiation
Cell Line
Female
Humans
Induced Pluripotent Stem Cells*
Leukocytes, Mononuclear
Middle Aged