Abstract
The modification of lipid A with cationic 4-amino-4-deoxy-l-arabinose residues serves to confer resistance against cationic peptide antibiotics in Gram-negative bacteria. In this work, the enzyme ArnD is shown to act as a metal-dependent deformylase in the biosynthesis of this carbohydrate.
MeSH terms
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Anti-Bacterial Agents*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Drug Resistance, Bacterial / genetics*
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Edetic Acid / pharmacology
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Gram-Negative Bacteria / enzymology*
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Lipid A / chemistry
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Lipid A / metabolism*
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Polymyxins*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Lipid A
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Polymyxins
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Edetic Acid