Cationic Peptidopolysaccharide with an Intrinsic AIE Effect for Combating Bacteria and Multicolor Imaging

Abstract

An antibacterial polymer peptidopolysaccharide (COS-AMP) that integrates antibacterial and detection functions is constructed with a simple synthetic method. The COS-AMP is constructed by simulating the structure of peptidoglycan of the bacterial cell wall with chitooligosaccharide with intrinsic aggregation-induced emission (AIE) effect as the main chain, as well as a peptide polymer grafted onto its amino group. Based on the AIE effect and excitation-dependent fluorescence of COS-AMP, it is tentatively applied to multicolor imaging and quantification of bacteria. This multicolor imaging helps to match different excitation sources of fluorescent instrument for straightforward imaging and detection. The structural similarity with the bacterial cell wall component facilitates the passage of COS-AMP across the cell wall and destroys the bacterial structure, thus it has a good broad-spectrum antibacterial activity. In addition, aromatic fluorophores are not needed, and excellent biocompatibility will make it have broad application prospects.

Keywords: aggregation-induced emission; antibacterial polymers; multicolor imaging; peptidopolysaccharide.