Abstract
The development of a highly effective photosensitizer (PS) that can be activated with a low-power single light is a pressing issue. Herein, we report a PS for synergistic photodynamic and photothermal therapy constructed through self-assembly of poly(selenoviologen) on the surface of core-shell NaYF4:Yb/Tm@NaYF4 upconversion nanoparticles. The hybrid UCNPs/PSeV PS showed strong ROS generation ability and high photothermal conversion efficiency (∼52.5%) under the mildest reported-to-date irradiation conditions (λ = 980 nm, 150 mW/cm2, 4 min), leading to a high efficiency in killing methicillin-resistant Staphylococcus aureus (MRSA) both in vitro and in vivo. Remarkably, after intravenous injection, the reported PS accumulated preferentially in deep MRSA-infected tissues and achieved an excellent therapeutic index. This PS design realizes a low-power single-NIR light-triggered synergistic phototherapy and provides a simple and versatile strategy to develop safe clinically translatable agents for efficient treatment of deep tissue bacterial inflammations.
Keywords:
chalcogen atoms; photodynamic therapy; photothermal therapy; upconversion nanoparticles; viologens.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / radiation effects
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Anti-Bacterial Agents / therapeutic use*
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Fluorides / chemistry
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Fluorides / radiation effects
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Hyperthermia, Induced / methods
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Infrared Rays
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Mice
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Microbial Sensitivity Tests
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Nanoparticles / chemistry
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Nanoparticles / radiation effects
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Nanoparticles / therapeutic use*
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Organoselenium Compounds / chemistry
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Organoselenium Compounds / radiation effects
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Organoselenium Compounds / therapeutic use*
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Photochemotherapy / methods
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / radiation effects
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Photosensitizing Agents / therapeutic use*
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Polymers / chemistry
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Polymers / radiation effects
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Polymers / therapeutic use
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Reactive Oxygen Species / metabolism
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Staphylococcal Infections / drug therapy*
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Thulium / chemistry
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Thulium / radiation effects
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Viologens / chemistry
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Viologens / radiation effects
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Viologens / therapeutic use*
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Ytterbium / chemistry
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Ytterbium / radiation effects
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Yttrium / chemistry
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Yttrium / radiation effects
Substances
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Anti-Bacterial Agents
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Organoselenium Compounds
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Photosensitizing Agents
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Polymers
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Reactive Oxygen Species
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Viologens
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sodium yttriumtetrafluoride
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Yttrium
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Thulium
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Ytterbium
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Fluorides