Potential SARS-CoV-2 Preimmune IgM Epitopes

Front Immunol. 2020 Apr 30:11:932. doi: 10.3389/fimmu.2020.00932. eCollection 2020.

Abstract

While studying the human public IgM igome as represented by a library of 224,087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein. Joining the efforts to fast track SARS-CoV-2 vaccine development, here we describe briefly these potential epitopes in comparison to mimotopes representing peptides of SARS-CoV, HCoV 229E and OC43.

Keywords: B cell precursors; IgM; SARS-CoV-2; epitope; mimotope.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / chemistry
  • Antibodies, Viral / immunology*
  • Betacoronavirus / immunology*
  • Epitopes / chemistry*
  • Humans
  • Immunoglobulin M / chemistry
  • Immunoglobulin M / immunology*
  • Peptides / chemistry
  • Peptides / immunology
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / immunology

Substances

  • Antibodies, Viral
  • Epitopes
  • Immunoglobulin M
  • Peptides
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2