Advanced "lab-on-a-chip" to detect viruses - Current challenges and future perspectives

Jianjian Zhuang; Juxin Yin; Shaowu Lv; Ben Wang; Ying Mu

doi:10.1016/j.bios.2020.112291

Advanced "lab-on-a-chip" to detect viruses - Current challenges and future perspectives

Biosens Bioelectron. 2020 Sep 1:163:112291. doi: 10.1016/j.bios.2020.112291. Epub 2020 May 12.

Authors

Jianjian Zhuang¹, Juxin Yin², Shaowu Lv³, Ben Wang⁴, Ying Mu⁵

Affiliations

¹ College of Life Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
² Research Centre for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China; Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China.
³ Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University, Changchun, 130000, China.
⁴ Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China; Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China.
⁵ Research Centre for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China; College of Life Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China. Electronic address: muying@zju.edu.cn.

Abstract

Massive viral outbreaks draw attention to viruses that have not been thoroughly studied or understood. In recent decades, microfluidic chips, known as "lab-on-a-chip", appears as a promising tool for the detection of viruses. Here, we review the development of microfluidic chips that could be used in response to viral detection, specifically for viruses involved in more recent outbreaks. The advantages as well as the disadvantages of microfluidic systems are discussed and analyzed. We also propose ideas for future development of these microfluidic chips and we expect this advanced technology to be used in the future for viral outbreaks.

Keywords: Lab on a chip; Microfluidic chip; Virus detection; Virus outbreak.

Publication types

Review

MeSH terms

Biosensing Techniques*
Lab-On-A-Chip Devices
Microfluidic Analytical Techniques*
Microfluidics
Viruses*