Evaluation of Vesical Imaging-Reporting and Data System (VI-RADS) scoring system in predicting muscle invasion of bladder cancer

Shenghua Liu; Feijia Xu; Tianyuan Xu; Yang Yan; Xudong Yao; Guangyu Tang

doi:10.21037/tau.2020.02.16

Evaluation of Vesical Imaging-Reporting and Data System (VI-RADS) scoring system in predicting muscle invasion of bladder cancer

Transl Androl Urol. 2020 Apr;9(2):445-451. doi: 10.21037/tau.2020.02.16.

Authors

Shenghua Liu¹, Feijia Xu², Tianyuan Xu¹, Yang Yan¹, Xudong Yao¹, Guangyu Tang²

Affiliations

¹ Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
² Department of Radiology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.

Abstract

Background: To investigate the accuracy of using the Vesical Imaging-Reporting and Data System (VI-RADS) scoring system in prediction preoperative muscle invasion of bladder cancer.

Methods: The study retrospectively reviewed consecutive patients with bladder cancer who received multiparametric magnetic resonance imaging (MRI) between January 2017 and June 2019. Clinical and pathological parameters were collected. Bladder tumors were re-evaluated with 5-point VI-RADS scoring system by two experienced radiologists independently. The VI-RADS score was compared with postoperative pathology for each tumor for determining muscle invasion. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each VI-RADS cutoff.

Results: A total of 126 patients were included in analysis, with 82 patients received transurethral resection of bladder tumor (TURBt) while 44 underwent radical cystectomy. Fifty patients were muscle-invasive bladder cancer and 76 were non-muscle invasive tumor confirmed pathologically. VI-RADS score was only predictive factor to muscle invasion in multivariate analysis. Setting VI-RADS score greater than or equal to 4 reached the best sensitivity and specificity of 94.00% and 92.11%, with PPV and NPV value of 88.68% and 95.89%.

Conclusions: VI-RADS score system is a promising and effective modality in determining detrusor muscle invasion of bladder cancer preoperatively.

Keywords: Bladder cancer; Vesical Imaging-Reporting and Data System (VI-RADS); multiparametric magnetic resonance imaging (mpMRI); muscle invasion; prediction.