Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease

Thomas Berger; Hyunah Lee; Allan H Young; Dag Aarsland; Sandrine Thuret

doi:10.1016/j.molmed.2020.03.010

Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease

Trends Mol Med. 2020 Sep;26(9):803-818. doi: 10.1016/j.molmed.2020.03.010. Epub 2020 May 14.

Authors

Thomas Berger¹, Hyunah Lee¹, Allan H Young², Dag Aarsland³, Sandrine Thuret⁴

Affiliations

¹ Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
² Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London and South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, Beckenham, Kent, UK.
³ Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
⁴ Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address: sandrine1.thuret@kcl.ac.uk.

PMID: 32418723
DOI: 10.1016/j.molmed.2020.03.010

Abstract

Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.

Keywords: Alzheimer’s disease; adult hippocampal neurogenesis; major depressive disorder.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / physiopathology*
Animals
Depressive Disorder, Major / physiopathology*
Hippocampus / physiopathology*
Humans
Neurogenesis / physiology*

Abstract

Publication types

MeSH terms

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