Abstract
Acute intermittent hypoxia (AIH) and task-specific training (TST) synergistically improve motor function after spinal cord injury; however, mechanisms underlying this synergistic relation are unknown. We propose a hypothetical working model of neural network and cellular elements to explain AIH-TST synergy. Our goal is to forecast experiments necessary to advance our understanding and optimize the neurotherapeutic potential of AIH-TST.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Brain-Derived Neurotrophic Factor / metabolism
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Exercise Therapy / methods*
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Hippocampus / metabolism
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Humans
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Hypoxia / physiopathology
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Membrane Glycoproteins / metabolism
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Motor Neurons / physiology*
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Neuronal Plasticity
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Receptor, trkB / metabolism
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Spinal Cord / metabolism
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Spinal Cord Injuries / physiopathology*
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Spinal Cord Injuries / rehabilitation*
Substances
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Brain-Derived Neurotrophic Factor
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Membrane Glycoproteins
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Receptor, trkB
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tropomyosin-related kinase-B, human