Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters

Meng Gao; Jian Huang; Xin Jiang; Yafei Yuan; Huanhuan Pang; Shuchen Luo; Nan Wang; Chengbo Yao; Zuwan Lin; Debing Pu; Shuo Zhang; Pengcheng Sun; Zhuoyi Liu; Yu Xiao; Qian Wang; Zeping Hu; Hang Yin

doi:10.1007/s13238-020-00725-7

Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters

Protein Cell. 2020 Jun;11(6):446-451. doi: 10.1007/s13238-020-00725-7.

Authors

Meng Gao^{1

2

3}, Jian Huang^{1

2

3}, Xin Jiang^{2

3

4

5}, Yafei Yuan^{2

3

4}, Huanhuan Pang⁶, Shuchen Luo^{1

2

3}, Nan Wang^{2

3

4}, Chengbo Yao^{1

2

3}, Zuwan Lin^{1

2

3}, Debing Pu^{2

3

6}, Shuo Zhang^{2

3

4}, Pengcheng Sun^{2

3

4}, Zhuoyi Liu^{1

2

3}, Yu Xiao⁷, Qian Wang⁷, Zeping Hu⁶, Hang Yin^{8

9

10}

Affiliations

¹ Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
² Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
³ Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, 100084, China.
⁴ State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
⁵ Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
⁶ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
⁷ Laboratory Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
⁸ Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, 100084, China. yin_hang@tsinghua.edu.cn.
⁹ Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, 100084, China. yin_hang@tsinghua.edu.cn.
¹⁰ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. yin_hang@tsinghua.edu.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aerobiosis / drug effects
Antineoplastic Agents / pharmacology*
Cell Proliferation / drug effects*
Glucose Transport Proteins, Facilitative / antagonists & inhibitors*
Glucose Transport Proteins, Facilitative / metabolism
Glycolysis / drug effects*
Humans
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Small Molecule Libraries / pharmacology*

Substances

Antineoplastic Agents
Glucose Transport Proteins, Facilitative
Small Molecule Libraries