Biodegradable poly(l-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity

Varvara A Demina; Sergei V Krasheninnikov; Alexander I Buzin; Roman A Kamyshinsky; Natalya V Sadovskaya; Evgeny N Goncharov; Natalya A Zhukova; Mikhail V Khvostov; Alla V Pavlova; Tatjana G Tolstikova; Nikita G Sedush; Sergei N Chvalun

doi:10.1016/j.msec.2020.110813

Biodegradable poly(l-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity

Mater Sci Eng C Mater Biol Appl. 2020 Jul:112:110813. doi: 10.1016/j.msec.2020.110813. Epub 2020 Mar 6.

Affiliations

¹ National Research Center Kurchatov Institute, pl. Akademika Kurchatova 1, Moscow 123098, Russia; Enikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia. Electronic address: demina.varvara@yandex.ru.
² National Research Center Kurchatov Institute, pl. Akademika Kurchatova 1, Moscow 123098, Russia.
³ National Research Center Kurchatov Institute, pl. Akademika Kurchatova 1, Moscow 123098, Russia; Enikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences, Profsoyuznaya St. 70, Moscow 117393, Russia.
⁴ National Research Center Kurchatov Institute, pl. Akademika Kurchatova 1, Moscow 123098, Russia; Shubnikov Institute of Crystallography of Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninskiy prospect, 59, Moscow 119333, Russia; Moscow Institute of Physics and Technology, Institutsky lane 9, Dolgoprudny, Moscow region 141700, Russia.
⁵ Shubnikov Institute of Crystallography of Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Leninskiy prospect, 59, Moscow 119333, Russia.
⁶ Central Clinical Hospital RAS, Fotieva St. 10, Moscow 119333, Russia; Russian Medical Academy of Continuous Professional Education, Barrikadnaya St. 2/1, Moscow 123995, Russia.
⁷ N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 9, Novosibirsk 630090, Russia.
⁸ N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 9, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.

PMID: 32409026
DOI: 10.1016/j.msec.2020.110813

Abstract

Biodegradable poly(l-lactide)/calcium phosphate composites are promising materials for fabrication of bone fixation implants with improved properties. Multistage compounding was proposed as an efficient method for the preparation of biodegradable poly(l-lactide)/calcium phosphate composites with submicron filler dispersion and mechanical characteristics similar to native bone. The improvement of the characteristics is caused both by the filler itself and by the increase of polymer crystallinity due to the nucleation effect. The technique allows to fabricate biodegradable composites with controlled properties by varying concentration and type of the filler as well as degree of PLLA matrix crystallinity. Animal studies revealed that all the composites were biocompatible and non-toxic.

Keywords: Biodegradable polymers; Bone tissue engineering; Hydroxyapatite; Polylactide; Polymer composites.

MeSH terms

Animals
Biocompatible Materials / chemistry*
Biocompatible Materials / metabolism
Biocompatible Materials / therapeutic use
Crystallization
Durapatite / chemistry*
Elastic Modulus
Male
Molecular Weight
Muscle, Skeletal / pathology
Polyesters / chemistry*
Prostheses and Implants
Rats
Rats, Wistar
Tensile Strength

Substances

Biocompatible Materials
Polyesters
poly(lactide)
Durapatite