The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis

David L Sacks

doi:10.1016/j.chom.2020.04.014

The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis

Cell Host Microbe. 2020 May 13;27(5):683-684. doi: 10.1016/j.chom.2020.04.014.

Author

David L Sacks¹

Affiliation

¹ Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: dsacks@nih.gov.

PMID: 32407702
DOI: 10.1016/j.chom.2020.04.014

Abstract

The phagosomal pathogen Leishmania appears unaffected by deliberate changes in the early Th1/Th2 balance. In this issue, Carneiro et al. explain these paradoxical results by showing that manipulations affecting IFN-γ-mediated phagocyte activation are counteracted by effects on IFN-γ-dependent recruitment of CCR2⁺ monocytes permissive to parasite growth.

Published by Elsevier Inc.

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MeSH terms

Humans
Interferon-gamma
Leishmaniasis*
Monocytes*
Phagosomes
Skin

Substances

Interferon-gamma