Human microbiome and homeostasis: insights into the key role of prebiotics, probiotics, and symbiotics

Crit Rev Food Sci Nutr. 2021;61(9):1415-1428. doi: 10.1080/10408398.2020.1760202. Epub 2020 May 13.

Abstract

The interest in the study of the gut microbiome has grown exponentially. Indeed, its impact on health and disease has been increasingly reported, and the importance of keeping gut microbiome homeostasis clearly highlighted. However, and despite many advances, there are still some gaps, as well as the real discernment on the contribution of some species falls far short of what is needed. Anyway, it is already more than a solid fact of its importance in maintaining health and preventing disease, as well as in the treatment of some pathologies. In this sense, and given the existence of some ambiguous opinions, the present review aims to discuss the importance of gut microbiome in homeostasis maintenance, and even the role of probiotics, prebiotics, and symbiotics in both health promotion and disease prevention.

Keywords: Human microbiome; gut microbiome; human physiology; infection; microbial; microbiome; prebiotic; probiotic; symbiotic.

Publication types

  • Review
  • Retracted Publication

MeSH terms

  • Gastrointestinal Microbiome*
  • Homeostasis
  • Humans
  • Prebiotics
  • Probiotics*

Substances

  • Prebiotics